The human serotonin transporter (5-HTT), encoded by a single gene on chromosome 17q11.2, is expressed in brain and blood cells. 5-HTT is implicated in mood and anxiety regulation, and is where antidepressant and antianxiety drugs initially act in the brain. A 5-HTT-linked promoter region (5-HTTLPR)
Identification of serotonin transporter mRNA in rat platelets
✍ Scribed by D. Hranilović; K. -P. Lesch; Đ. Ugarković; L. Čičin-Šain; B. Jernej
- Publisher
- Springer
- Year
- 1996
- Tongue
- English
- Weight
- 704 KB
- Volume
- 103
- Category
- Article
- ISSN
- 1435-1463
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The circadian rhythm of serotonin active transport in human platelets was investigated in ten healthy men, aged 27-35 years. Blood was collected at 08.00, 14.00, 20.00, 02.00 and 08.00 hours the next morning. Simultaneous evaluation of the mean platelet volume, platelet distribution width, platelet
## Abstract The serotonin (5HT) transporter (5HTT) regulates serotonergic neurotransmission by mediating the reuptake of 5HT from the synaptic cleft. Although lacking the high affinity and selectivity of the 5HTT, the brain expresses a large number of other transporters, including the polyspecific