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Identification of selected antihypertensive drugs by thin-layer chromatography

✍ Scribed by Jack E. Wallace; Horace E. Hamilton; Harold Skrdlant; Larry L. Burkett; Harvey Schwertner

Publisher
Elsevier Science
Year
1977
Tongue
English
Weight
631 KB
Volume
138
Category
Article
ISSN
1873-3778

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✦ Synopsis

A thin-layer chromatographic procedure is described for the qualitative identification of several antihypertensive drugs including certain thiazide diuretics, spironolactone, triamterene, methyldopa and their metabolites. Utilization of new solvent developing systems and spray detecting reagents provides a method useful for the identification of these compounds in biologic fluids at low therapeutic concentrations. Sensitivity limits for these antihypertensive drugs are given, and alternate techniques to provide confhmatory analyses are also presented.

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