The elimination and metabolism of [14-C]-tetrachloroethylene (Tetra) was studied in female rats and mice after the oral administration of 800 mg/kg [14-C]-Tetra. Elimination of unchanged Tetra was the main pathway of elimination in both species and amounted to 91.2% of the dose in rats and 85.1% in
โฆ LIBER โฆ
Identification of S-1,2-dichlorovinyl-N-acetyl-cysteine as a urinary metabolite of trichloroethylene: A possible explanation for its nephrocarcinogenicity in male rats
โ Scribed by Wolfgang Dekant; Manfred Metzler; Dietrich Henschler
- Book ID
- 115778714
- Publisher
- Elsevier Science
- Year
- 1986
- Tongue
- English
- Weight
- 297 KB
- Volume
- 35
- Category
- Article
- ISSN
- 0006-2952
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1-Cyano-3,4-epithiobutane (CEB), a naturally occurring nitrile derived from cruciferous plants, causes nephrotoxicity in male Fischer 344 rats. Nephrotoxicity induced by CEB is dependent on glutathione (GSH) conjugation and bioactivation. Conjugation with GSH and subsequent metabolism leads to the f