Identification of proteins by their amino acid composition: An evaluation of the method
β Scribed by Dr. Olivier Golaz; Marc R. Wilkins; Jean-Charles Sanchez; Ron D. Appel; Denis F. Hochstrasser; Keith L. Williams
- Publisher
- John Wiley and Sons
- Year
- 1996
- Tongue
- English
- Weight
- 696 KB
- Volume
- 17
- Category
- Article
- ISSN
- 0173-0835
No coin nor oath required. For personal study only.
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A critical overview is given on the application of amino acid composition data for the establishment of the protein's identity (amino acids composition vs. protein identity, the AAC-PI method). Several criteria are used to measure the differences between the amino acid compositions of various protei
Having obtained the amino acid composition of a protein, chemists and molecular biologists may wish to identify the protein from this data alone. In general such data will have errors associated with them and the length of the protein may be known only approximately or not at all. In this paper a me
## Abstract Correspondence analysis of 28 proteomes selected to span the entire realm of prokaryotes revealed universal biases in the proteins' amino acid distribution. Integral Inner Membrane Proteins always form an individual cluster, which can then be used to predict protein localisation in unkn
Knowledge of amino acid composition, alone, is verified here to be sufficient for recognizing the structural class, alpha, beta, alpha + beta, or alpha/beta of a given protein with an accuracy of 81%. This is supported by results from exhaustive enumerations of all conformations for all sequences of