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Identification of PR-SET7 and EZH2 selective inhibitors inducing cell death in human leukemia U937 cells

✍ Scribed by Valente, Sergio; Lepore, Ilaria; Dell'Aversana, Carmela; Tardugno, Maria; Castellano, Sabrina; Sbardella, Gianluca; Tomassi, Stefano; Di Maro, Salvatore; Novellino, Ettore; Di Santo, Roberto; Costi, Roberta; Altucci, Lucia; Mai, Antonello


Book ID
119195825
Publisher
Elsevier Science
Year
2012
Tongue
English
Weight
398 KB
Volume
94
Category
Article
ISSN
0300-9084

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## Abstract Arsenite has been reported to exert dose‐dependent dual effects: triggering apoptosis at relatively high concentrations, whereas inducing partial differentiation at low concentrations in leukemia cells. However, the relevant molecular mechanisms of its action at low and nonapoptotic con