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Identification of Potent, Selective, and Metabolically Stable Peptide Antagonists to the Calcitonin Gene-Related Peptide (CGRP) Receptor

✍ Scribed by Miranda, Les P.; Holder, Jerry Ryan; Shi, Licheng; Bennett, Brian; Aral, Jennifer; Gegg, Colin V.; Wright, Marie; Walker, Kenneth; Doellgast, George; Rogers, Rick; Li, Hongyan; Valladares, Violeta; Salyers, Kevin; Johnson, Eileen; Wild, Kenneth


Book ID
126944330
Publisher
American Chemical Society
Year
2008
Tongue
English
Weight
579 KB
Volume
51
Category
Article
ISSN
0022-2623

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## Abstract Calcitonin gene‐related peptide (CGRP), a potent dilator of cerebral and dural vasculature, is known to be elevated in plasma and cerebral spinal fluid during migraine attacks. Selective blockade of the CGRP receptor offers the promise of controlling migraine headache more effectively a