๐”– Bobbio Scriptorium
โœฆ   LIBER   โœฆ

Identification of Peptide Ligands for Targeting to the Blood-Brain Barrier

โœ Scribed by Inge van Rooy; Serpil Cakir-Tascioglu; Pierre-Olivier Couraud; Ignacio A. Romero; Babette Weksler; Gert Storm; Wim E. Hennink; Raymond M. Schiffelers; Enrico Mastrobattista


Publisher
Springer US
Year
2010
Tongue
English
Weight
359 KB
Volume
27
Category
Article
ISSN
0724-8741

No coin nor oath required. For personal study only.


๐Ÿ“œ SIMILAR VOLUMES


The role of peptides in blood-brain barr
โœ Meritxell Teixidรณ; Ernest Giralt ๐Ÿ“‚ Article ๐Ÿ“… 2008 ๐Ÿ› John Wiley and Sons ๐ŸŒ English โš– 409 KB

## Abstract The bloodโ€brain barrier (BBB) regulates the passage of molecules between the bloodstream and the brain. Overcoming the difficulty of delivery drugs to specific areas of the brain is a major challenge. The BBB exerts a neuroprotective function as it hinders the delivery of diagnostic and

GDNF fusion protein for targeted-drug de
โœ Ruben J. Boado; Yun Zhang; Yufeng Zhang; Yuntao Wang; William M. Pardridge ๐Ÿ“‚ Article ๐Ÿ“… 2008 ๐Ÿ› John Wiley and Sons ๐ŸŒ English โš– 255 KB ๐Ÿ‘ 2 views

## Abstract Glialโ€derived neurotrophic factor (GDNF) is a neurotrophin that could be developed as a neurotherapeutic for Parkinson's disease, stroke, and motor neuron disease. However, GDNF does not cross the bloodโ€“brain barrier (BBB). Human GDNF was reโ€engineered by fusion of the mature GDNF prote

Humanization of anti-human insulin recep
โœ Ruben J. Boado; Yufeng Zhang; Yun Zhang; William M. Pardridge ๐Ÿ“‚ Article ๐Ÿ“… 2006 ๐Ÿ› John Wiley and Sons ๐ŸŒ English โš– 283 KB ๐Ÿ‘ 2 views

## Abstract A murine monoclonal antibody (MAb) to the human insulin receptor (HIR) has been engineered for use as a brain drug delivery system for transport across the human bloodโ€“brain barrier (BBB). The HIRMAb was humanized by complementarity determining region (CDR) grafting on the framework reg

Rational identification of a novel pepti
โœ Abhiruchi Agarwal; David L. Jaye; Cissy M. Giegerman; Ravi V. Bellamkonda ๐Ÿ“‚ Article ๐Ÿ“… 2008 ๐Ÿ› John Wiley and Sons ๐ŸŒ English โš– 151 KB

## Abstract Traditional therapies for high grade gliomas are limited in part by collateral damage to normal tissues. Selective delivery of therapies to tumors is, therefore, needed. Here, we report that liposomal nanocarriers coated with a novel oligopeptide enhance uptake by 9L gliosarcoma. A targ