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Identification of PAX3/FKHR fusion transcripts in three metastatic alveolar rhabdomyosarcomas showing cytogenetic variants of the t(2; 13)

✍ Scribed by D. López-Terrada; R. Tirabosco; M.Y. Cui; H. Affendie; T.J. Triche; M.Y. Cui; H. Affendie; T.J. Triche

Book ID
113253869
Publisher
Elsevier Science
Year
1995
Tongue
English
Weight
186 KB
Volume
84
Category
Article
ISSN
0165-4608

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Detection of the t(2;13)(q35;q14) and PA
Detection of the t(2;13)(q35;q14) and PAX3-FKHR fusion in alveolar rhabdomyosarcoma by fluorescence in situ hybridization
✍ Jaclyn A. Biegel; Lynn M. Nycum; Virginia Valentine; Frederic G. Barr; David N. 📂 Article 📅 1995 🏛 John Wiley and Sons 🌐 English ⚖ 600 KB

Cytogenetic studies of the pediatric solid tumor alveolar rhabdomyosarcoma have demonstrated the presence of a consistent chromosomal translocation, t(2 I3)(q35;q 14). We recently identified PAX3 and FKHR as the genes on chromosomes 2 and I 3, respectively, that are juxtaposed by this translocation.