Identification of novel pathway regulation during myogenic differentiation
β Scribed by Joseph D. Szustakowski; Jee-Hyung Lee; Christine A. Marrese; Penelope A. Kosinski; N.R. Nirmala; Daniel M. Kemp
- Book ID
- 116981459
- Publisher
- Elsevier Science
- Year
- 2006
- Tongue
- English
- Weight
- 585 KB
- Volume
- 87
- Category
- Article
- ISSN
- 0888-7543
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## Abstract Phospholipase C Ξ²~1~ (PLCΞ²~1~) signaling in both cell proliferation and differentiation has been largely investigated, but its role in myoblast differentiation is still unclear. The C2C12 myogenic cell line has been used in this study in order to find out the role of the two subtypes of
In our preceding report, we have shown that nerve growth factor (NGF) and its low-affinity receptor (p75 NTR ) are expressed in C2C12 myoblasts and downregulated during myogenic differentiation. Furthermore, NGF affects myogenic differentiation and cell growth via p75 NTR and downregulation of p75 N