Identification of novel E6-E7 sequence variants of human papillomavirus 16
โ Scribed by Tsakogiannis, D.; Kyriakopoulou, Z.; Amoutzias, G.; Ruether, I. G. A.; Dimitriou, T. G.; Panotopoulou, E.; Markoulatos, P.
- Book ID
- 118278762
- Publisher
- Springer Vienna
- Year
- 2012
- Tongue
- English
- Weight
- 337 KB
- Volume
- 158
- Category
- Article
- ISSN
- 1432-8798
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## Abstract Genetic variations in the E6 oncogene have been associated with different risk for cancer progression. In the present study, the functional significance of human papillomavirus (HPV) polymorphism in the E6 oncogene was investigated. Ten HPV16 E6 variants containing amino acid substituti
## Abstract The human papillomavirus (HPV) 16 genome has been studied extensively, although no study has focused on the E1 gene that is implicated in viral DNA replication. After analyzing the E1 region of HPV 16 genomes in 429 cervical samples, 11.2% were found to contain a 63 nucleotides duplicat