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Identification of novel chromosomal rearrangements in acute myelogenous leukemia involving loci on chromosome 2p23, 15q22 and 17q21

โœ Scribed by Melnick, A; Fruchtman, S; Zelent, A; Liu, M; Huang, Q; Boczkowska, B; Calasanz, MJ; Fernandez, A; Licht, JD; Najfeld, V


Book ID
110054301
Publisher
Nature Publishing Group
Year
1999
Tongue
English
Weight
90 KB
Volume
13
Category
Article
ISSN
0887-6924

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Identification of a novel fusion gene ML
โœ Noriko Nemoto; Kazumi Suzukawa; Seiichi Shimizu; Atsushi Shinagawa; Naoko Takei; ๐Ÿ“‚ Article ๐Ÿ“… 2007 ๐Ÿ› John Wiley and Sons ๐ŸŒ English โš– 423 KB

## Abstract We have identified a novel fusion partner of __MLL__, namely the mastermind like 2 (__MAML____2__ gene), in secondary acute myeloid leukemia (AML) and myelodysplastic syndrome (MDS) with inv(11)(q21q23). RTโ€PCR and sequencing revealed that exon 7 of __MLL__ was fused to exon 2 of __MAML