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Identification of novel allosteric modulators for the G-protein coupled US28 receptor of human cytomegalovirus

✍ Scribed by Ana Kralj; Alexander Wetzel; Shohreh Mahmoudian; Thomas Stamminger; Nuska Tschammer; Markus R. Heinrich

Book ID
113495929
Publisher
Elsevier Science
Year
2011
Tongue
English
Weight
402 KB
Volume
21
Category
Article
ISSN
0960-894X

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## Abstract The human cytomegalovirus (HCMV)‐encoded chemokine receptor US28 is also a seven‐transmembrane G‐protein coupled receptor, whose signaling pathway is known for its involvement in host immune system evasion. HCMV infection can result in serious disease in immunocompromised individuals an