Identification of TAAs recognized by CD8(+) CTLs paved the way for new concepts in cancer therapy. In view of the heterogeneity of tumors and their diverse escape mechanisms, CTL-based cancer therapy largely depends on an appropriate number of TAAs. In prostate cancer, the number of antigens defined
Identification of new prostate stem cell antigen-derived peptides immunogenic in HLA-A2+patients with hormone-refractory prostate cancer
β Scribed by Satoko Matsueda; Kazuhiko Kobayashi; Yoichi Nonaka; Masanori Noguchi; Kyogo Itoh; Mamoru Harada
- Publisher
- Springer-Verlag
- Year
- 2004
- Tongue
- English
- Weight
- 472 KB
- Volume
- 53
- Category
- Article
- ISSN
- 0340-7004
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## Background: A phase ii trial was conducted to assess the efficacy of infusions of dendritic cells (dc) and two hla-a2-specific psma peptides (psm-p1 and -p2). this report describes thirty three subjects with hormone-refractory metastatic prostate cancer without prior vaccine therapy history who
## BACKGROUND. In this paper we describe our program for the immune monitoring of phase II participants given dendritic cell (DC)/prostate-specific membrane antigen (PSMA)-based immunotherapy, and we also present some initial findings. METHODS. Phase II subjects received six administrations of aut