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Identification of new checkpoint kinase-1 (Chk1) inhibitors by docking, 3D-QSAR, and pharmacophore-modeling methods

✍ Scribed by Ambre, Premlata K.; Pissurlenkar, Raghuvir R. S.; Coutinho, Evans C.; Iyer, Radhakrishnan P.


Book ID
118742615
Publisher
NRC Research Press
Year
2012
Tongue
French
Weight
644 KB
Volume
90
Category
Article
ISSN
0008-4042

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## Abstract Developing chemicals that inhibit checkpoint kinase 1 (Chk1) is a promising adjuvant therapeutic to improve the efficacy and selectivity of DNA‐targeting agents. Reliable prediction of binding‐free energy and binding affinity of Chk1 inhibitors can provide a guide for rational drug desi