Identification of N-alkyl substituted products by a dealkylation reaction in the presence of adsorption chromatography substrates
✍ Scribed by Carlo Prandi
- Publisher
- Elsevier Science
- Year
- 1970
- Tongue
- English
- Weight
- 603 KB
- Volume
- 48
- Category
- Article
- ISSN
- 1873-3778
No coin nor oath required. For personal study only.
✦ Synopsis
Some N-alkyl substituted products are partially or completely dealkylated when heated in the adsorbed state on silica gel or alumina. This reac,tion could be carried out either on a microscale, by direct heating of the thin-layer chromatography plates on which the sample has been spotted and eluting it together with the untreated product and with the probable degradation products, or on a macroscale, by adsorbing the sample on alumina or silica, heating and then extracting the dealkylation products with suitable solvents.
Advantage could be taken of this reaction to identify unknown substances as the dealkylation product of an unknown product could be identified after comparison with standards by thin-layer chromatography.
Furthermore, by working on a macroscale, it is possible to prepare the dealkylated product in amounts sufficient for elementary analysis and infrared spectrophotometry.
The reaction mechanism is discussed.