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Identification of Microorganisms by Mass Spectrometry (Wilkins/Identification of Microorganisms by Mass Spectrometry) || Development of Spectral Pattern-Matching Approaches to Matrix-Assisted Laser Desorption/Ionization Time-of-Flight Mass Spectrometry for Bacterial Identification

โœ Scribed by Wilkins, Charles L.; Lay, Jackson O.

Publisher
John Wiley & Sons, Inc.
Year
2006
Weight
60 KB
Category
Article
ISBN
0471748641

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โœฆ Synopsis

The concept of rapid microorganism identification using matrix-assisted laser desorption/ionization mass spectrometry (MALDI MS) dates back to the mid-1990s. Prior to 1998 researchers relied on visual inspection in an effort to demonstrate feasibility of MALDI MS for bacterial identification. [1][2][3] In general, researchers in these early studies visually compared the biomarker intensity profiles between different organisms and between replicates of the same organism to show that MALDI signatures are unique and reproducible.

Manual tabulation and comparison of potential biomarker mass values observed for different organisms was used by numerous researchers to qualitatively characterize microorganisms using MALDI mass spectra. [4][5][6][7]

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