Identification of Inhibitors of Protein Kinase B Using Fragment-Based Lead Discovery †
✍ Scribed by Saxty, Gordon; Woodhead, Steven J.; Berdini, Valerio; Davies, Thomas G.; Verdonk, Marcel L.; Wyatt, Paul G.; Boyle, Robert G.; Barford, David; Downham, Robert; Garrett, Michelle D.; Carr, Robin A.
- Book ID
- 120280736
- Publisher
- American Chemical Society
- Year
- 2007
- Tongue
- English
- Weight
- 278 KB
- Volume
- 50
- Category
- Article
- ISSN
- 0022-2623
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📜 SIMILAR VOLUMES
Protein kinases are now the second largest group of drug targets, and most protein kinase inhibitors in clinical development are directed towards the ATP-binding site. However, these inhibitors must compete with high intracellular ATP concentrations and they must discriminate between the ATP-binding
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