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Identification of immunodominant HLA-B7-restricted CD8+cytotoxic T cell epitopes derived from mammaglobin-A expressed on human breast cancers

✍ Scribed by Haseeb Ilias Basha; Venkataswarup Tiriveedhi; Timothy P. Fleming; William E. Gillanders; T. Mohanakumar

Publisher
Springer US
Year
2010
Tongue
English
Weight
426 KB
Volume
127
Category
Article
ISSN
0167-6806

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## Abstract Mammaglobin‐A is highly overexpressed in breast cancer cell lines and primary breast tumors. This pattern of expression is restricted to mammary epithelium and metastatic breast tumors. Thus, mammaglobin‐A‐specific T cell immune responses may provide an important approach for the design