Stimulation of central histamine H, and or H, receptors with histaminergic drugs results in a dose-related pressor response and bradycardia in conscious, freely-moving rats. Two recently developed peripheral histamine H, antagonists, MK-208 and BMY-26368, as well as cimetidine, were evaluated with r
✦ LIBER ✦
Identification of histamine H1- and H2-receptors by means of mepyramine, cimetidine and theophylline in the cardiovascular system of the dog
✍ Scribed by D. Reinhardt; R. Walkenhorst; G. Arnold
- Publisher
- SP Birkhäuser Verlag Basel
- Year
- 1980
- Tongue
- English
- Weight
- 458 KB
- Volume
- 10
- Category
- Article
- ISSN
- 1420-908X
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The effects of pyrilamine and burimamide (histamine HIand H2-receptor blockers, respectively) on the hypothermic response to histidine loading have been studied in rats. The antagonists were injected into one of three sites in the brain: the preoptic/ anterior hypothalamic nuclei, the lateral ventri