Identification of glucokinase mutation in subjects with post-renal transplantation diabetes mellitus
β Scribed by Jae-Hyun Nam; Hyun-Chul Lee; Youn-Hee Kim; Bong-Su Cha; Young-Duk Song; Sung-Kil Lim; Kyung-Rae Kim; Kap-Bum Huh
- Book ID
- 117369313
- Publisher
- Elsevier Science
- Year
- 2000
- Tongue
- English
- Weight
- 315 KB
- Volume
- 50
- Category
- Article
- ISSN
- 0168-8227
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## Maturity -onset diabetes of the young (MODY) is a clinically heterogeneous group of disorders characterized by early onset non-insulin-dependent diabetes mellitus, autosomal dominant inheritance, and primary defect in the function of the beta cells of the pancreas. Mutations in the glucokinase
Mutations were screened for in the glucokinase gene of 25 Japanese patients with Type 2 (non-insulin-dependent) diabetes mellitus. Each exon was scanned by electrophoresis of enzymatically amplified DNA segments under non-denaturing conditions and variants were sequenced. A variant pattern was detec