Identification of genetic alterations in upper urinary tract urothelial carcinoma in end-stage renal disease patients
✍ Scribed by Ching-Fang Wu; See-Tong Pang; Jia-Jen Shee; Phei-Lang Chang; Cheng-Keng Chuang; Chih-Shou Chen; Shuen-Kuei Liao; Wen-Hui Weng
- Publisher
- John Wiley and Sons
- Year
- 2010
- Tongue
- English
- Weight
- 152 KB
- Volume
- 49
- Category
- Article
- ISSN
- 1045-2257
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✦ Synopsis
Abstract
Clinical presentations of end‐stage renal disease (ESRD) patients on dialysis with upper urinary tract urothelial carcinoma (UUT‐UC) are different from those with normal renal function. The pathogenesis remains unknown. We investigated the pathogenetic influence of chromosomal aberrations in patient on dialysis with UUT‐UC. The chromosomal aberrations of UUT‐UC specimens from seven dialysis patients were assessed by conventional comparative genomic hybridization (cCGH). Subsequently, we further investigated 20 cases by whole genome and fine‐tiling oligonucleotide array‐based CGH to demonstrate gains and losses, and compared with the clinicopathologic background. The chromosomal aberrations in UUT‐UC specimens from dialysis patients were more complex than in bladder urothelial carcinoma (B‐UC). Our data showed that gains at 5p, 7, 19q, and losses at 4q, 9p, and 15q are common in UUT‐UC of ESRD patients. Gains in regions associated with DNA repair genes were noted in this study. High‐stage and high‐grade tumors displayed more copy number variants. In addition, female ESRD patients with UUT‐UC had more frequent chromosomal aberrations than their male counterparts. In conclusion, unique chromosomal aberrations were indentified in UUT‐UC in ESRD patients. © 2010 Wiley‐Liss, Inc.