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Identification of genes for bone mineral density variation by computational disease gene identification strategy

✍ Scribed by Gloria H. Y. Li; Hong-Wen Deng; Annie W. C. Kung; Qing-Yang Huang

Publisher: Springer
Year: 2011
Tongue: English
Weight: 312 KB
Volume: 29
Category: Article
ISSN: 0914-8779
DOI: 10.1007/s00774-011-0271-y

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## Abstract Sly disease (MPS VII) is an autosomal‐recessive lysosomal storage disorder resulting from beta‐glucuronidase deficiency, which is characterized by a severe neurological impairment. MPS VII mice accumulate undegraded glycosaminoglycans and mimic the human neurodegenerative disorder, thus