Identification of Genes Coding for Tumor Antigens Recognized by Cytolytic T Lymphocytes
✍ Scribed by Etienne De Plaen; Christophe Lurquin; Bernard Lethé; Pierre van der Bruggen; Vincent Brichard; Jean-Christophe Renauld; Pierre Coulie; Aline Van Pel; Thierry Boon
- Book ID
- 115638790
- Publisher
- Elsevier Science
- Year
- 1997
- Tongue
- English
- Weight
- 467 KB
- Volume
- 12
- Category
- Article
- ISSN
- 1046-2023
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Human melanoma line MZ2-MEL expresses several antigens recognized by autologous cytolytic T lymphocytes (CTL). As a first step towards the cloning of the gene coding for one of these antigens, we tried to obtain transfectants expressing the antigen. The DNA recipient cell was a variant of MZ2-MEL wh
Several tumor antigens recognized by T cells have now been identified at the molecular level. Various mechanisms can account for their expression: activation of normally silent genes; point mutations; chromosome translocations; and post-translational modifications of proteins. This led to the notion