Identification of Gene Expression Changes Induced by Chemical Allergens in Dendritic Cells: Opportunities for Skin Sensitization Testing

Allergen-induced changes in interleukin

Allergen-induced changes in interleukin 1β (iL-1β) mRNA expression by human blood-derived dendritic cells: inter-individual differences and relevance for sensitization testing

✍ Johanna S. Pichowski; Marie Cumberbatch; Rebecca J. Dearman; David A. Basketter; 📂 Article 📅 2001 🏛 John Wiley and Sons 🌐 English ⚖ 99 KB

The development of in vitro methods for the identification of skin sensitizers based upon analysis of Langerhans cell (LC) function has been constrained by the fact that these cells represent only a minority population in the skin that, once isolated, alter their phenotype spontaneously and rapidly.