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Identification of galectins as novel regulators of platelet signaling and function

✍ Scribed by Maria Albertina Romaniuk; Soledad Negrotto; Oscar Campetella; Gabriel Adrian Rabinovich; Mirta Schattner

Publisher
John Wiley and Sons
Year
2011
Tongue
English
Weight
516 KB
Volume
63
Category
Article
ISSN
1521-6543

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✦ Synopsis

Abstract

Platelet activation at sites of vascular injury leads to the formation of a hemostatic plug. Activation of platelets is therefore crucial for normal hemostasis. However, uncontrolled platelet activation may also lead to the formation of occlusive thrombi that can cause ischemic events. Platelets can be activated by soluble molecules including thrombin, TXA~2~, adenosine diphosphate (ADP), and serotonin or by adhesive extracellular matrix (ECM) proteins such as von Willebrand factor and collagen. In this article, we review recent advances on the role of galectins in platelet physiology. By acting in either soluble or immobilized form, these glycan‐binding proteins trigger platelet activation through modulation of discrete signaling pathways. We also offer new hypotheses and some speculations about the role of platelet–galectin interactions not only in hemostasis and thrombosis but also in inflammation and related diseases such as atherosclerosis and cancer. © 2011 IUBMB IUBMB Life, 63(7): 521–527, 2011

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