## Abstract Hepatocellular carcinoma (HCC) is one of the deadliest forms of human liver cancer and does not respond well to conventional therapies. Novel effective treatments are urgently in need. G‐protein‐coupled kinase 2 (GRK2) is unique serine/threonine kinase that involves in many signaling pa
✦ LIBER ✦
Identification of G protein-coupled receptors potently stimulating migration of human transitional-cell carcinoma cells
✍ Scribed by G. Lümmen; Sebastian Virchow; Ulrich Rümenapp; Martina Schmidt; Thomas Wieland; Thomas Otto; Herbert Rübben; Karl H. Jakobs
- Publisher
- Springer-Verlag
- Year
- 1997
- Tongue
- English
- Weight
- 123 KB
- Volume
- 356
- Category
- Article
- ISSN
- 0028-1298
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## Abstract Pleiotrophin (PTN) is a secreted growth factor involved in angiogenesis and tumor growth. We have recently shown that low concentrations of hydrogen peroxide (HP) stimulate PTN expression, through activation of the transcription factor AP‐1. In the present work, we studied the possible