A synthetic peptide, which was shown to bind extracellular matrix heparan sulfate chains with a high degree of affinity and specificity [Colburn et al. (1996): Arch Biochem Biophys 325:129-138], has now been found to promote the transfer and the deposition of endothelial cell surface proteoglycans i
Identification of Extracellular Matrix Ligands for the Heparan Sulfate Proteoglycan Agrin
β Scribed by Susan L. Cotman; Willi Halfter; Gregory J. Cole
- Book ID
- 115603280
- Publisher
- Elsevier Science
- Year
- 1999
- Tongue
- English
- Weight
- 400 KB
- Volume
- 249
- Category
- Article
- ISSN
- 0014-4827
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## Abstract Exposure of endothelial cells to heparin and other antithrombotic drugs specifically stimulates the synthesis of an antithrombotic heparan sulfate (HS). In the present work, biotinylated heparin (BiotHep) was used to characterize the binding site(s) of heparin responsible for the stimul