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Identification of Evi-1 as a novel effector of PKCδ in the apoptotic response to DNA damage

✍ Scribed by Hoi Chin Hew; Hanshao Liu; Zheng-Guang Lu; Junko Kimura; Yoshio Miki; Kiyotsugu Yoshida

Book ID
116272632
Publisher
Elsevier
Year
2011
Tongue
English
Weight
986 KB
Volume
1809
Category
Article
ISSN
1874-9399

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## Abstract The p53 tumor suppressor gene, which is frequently mutated in a wide variety of tumors, plays an important role in maintaining genomic integrity. Following genotoxic insults, the protein level of p53 is increased, and p53 functions as a sequence‐specific transcription factor that regula