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Identification of eukaryotic elongation factor-2 as a novel cellular target of lithium and glycogen synthase kinase-3

✍ Scribed by Racheli Karyo; Yael Eskira; Albert Pinhasov; RH Belmaker; Galila Agam; Hagit Eldar-Finkelman


Book ID
116735639
Publisher
Elsevier Science
Year
2010
Tongue
English
Weight
687 KB
Volume
45
Category
Article
ISSN
1044-7431

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## Abstract Certain environmental factors including drugs exacerbate or precipitate psoriasis. Lithium is the commonest cause of drug‐induced psoriasis but underlying mechanisms are currently unknown. Lithium inhibits glycogen synthase kinase 3 (GSK‐3). As lithium does not exacerbate other T‐cell‐m