Human papillomavirus type I 6 (HPV-16) is associated with neoplastic lesions of the uterine cervix. Viral transforming functions have been localized to the E&E7 open reading frame (ORF) and this ORF is conserved consistently in cervical intraepithelial neoplasia (CIN). Two mRNAs, generated by altern
Identification of E6/E7 Transcription Patterns in HPV 16-Positive Cervical Cancers Using the Reverse Transcription/Polymerase Chain Reaction
β Scribed by Barbara R. Rose; Carol H. Thompson; Martin H.N. Tattersall; Peter M. Elliott; Christopher Dalrymple; Yvonne E. Cossart
- Book ID
- 115616440
- Publisher
- Elsevier Science
- Year
- 1995
- Tongue
- English
- Weight
- 346 KB
- Volume
- 56
- Category
- Article
- ISSN
- 0090-8258
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## Abstract The oncogenic potential of the highβrisk human papillomavirus (HPV) genotypes (types 16, 18, 31, 33, 35, 39, 45, 51, 52, 56, 58, 59, 66 and 68) depends on the expression of the two viral oncogenes E6 and E7. Thus, the detection of HPV E6/E7 oncogene transcripts could serve as a factor i
Tissue from I I cases of cervical cancer positive for human papillomavirus (HPV) type I 6 DNA and 69 pelvic lymph nodes from the same patients were examined for HPV 16 DNA and mRNA from the E6/E7 genes. Five of the tumors were squamom, 3 adeno-and 3 adenosquamous carcinoma. From the primary tumors a