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Identification of DNA polymorphisms associated with the V type α1-antitrypsin gene

✍ Scribed by Marie-Christine Gaillard; Ravi Mahadeva; David A. Lomas

Book ID
114148457
Publisher
Elsevier Science
Year
1999
Tongue
English
Weight
399 KB
Volume
1444
Category
Article
ISSN
0167-4781

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Chronic liver disease affects up to 20% of children with alpha 1-antitrypsin deficiency owing to the PiZZ genotype. Previous observations of a familial occurrence and abnormal immune responses to liver antigens in these patients suggests that immunoregulatory genes may be involved in the pathogenesi