Kinetics of myc-max-mad gene expression
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Itsaso Mauleon; Marie-Noรซlle Lombard; Maria J. Muรฑoz-Alonso; Matilde Caรฑelles; J
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Article
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2004
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John Wiley and Sons
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English
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## Abstract Mad proteins (Mad1, Mxi1, Mad3, Mad4, Mnt/Rox) are biochemical and biological antagonists of cโMyc oncoprotein. MadโMax dimers repress the transcription of the same target genes activated by MycโMax dimers. Despite the critical role of Max and Mad proteins as modulators of cโMyc functio