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Identification of differentially regulated gene targets in the Myc and Mad family proteins

โœ Scribed by O'Hagan, Ronan; Schreiber-Agus, Nicole; Engelman, Jeffrey A.; Schwab, Richard; Alland, Leila; Thompson, Cole; Ronning, Donald R.; Sacchettini, James C.; Meltzer, Paul; DePinho, Ronald A.


Book ID
109530717
Publisher
Nature Publishing Group
Year
1999
Tongue
English
Weight
90 KB
Volume
23
Category
Article
ISSN
1061-4036

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## Abstract Mad proteins (Mad1, Mxi1, Mad3, Mad4, Mnt/Rox) are biochemical and biological antagonists of cโ€Myc oncoprotein. Madโ€Max dimers repress the transcription of the same target genes activated by Mycโ€Max dimers. Despite the critical role of Max and Mad proteins as modulators of cโ€Myc functio