𝔖 Bobbio Scriptorium
✦   LIBER   ✦

Identification of degradation products in a phenylbutazone tablet formulation

✍ Scribed by F. Matsui; D. L. Robertson; M. A. Poirier; E. G. Lovering

Publisher
John Wiley and Sons
Year
1980
Tongue
English
Weight
360 KB
Volume
69
Category
Article
ISSN
0022-3549

No coin nor oath required. For personal study only.

📜 SIMILAR VOLUMES

Identification of degradation products i
Identification of degradation products in stressed tablets of Rabeprazole sodium by HPLC-hyphenated techniques
✍ R. Vasu Dev; G. Sai Uday Kiran; B. Venkata Subbaiah; B. Suresh Babu; J. Moses Ba 📂 Article 📅 2009 🏛 John Wiley and Sons 🌐 English ⚖ 189 KB

## Abstract Three unknown impurities of Rabeprazole, a proton pump inhibitor, were formed in the formulated drug under the stress conditions, [40 °C/75% relative humidity (RH) for 6 months] with relative retention times (RRTs) 0.17, 0.22 and 0.28. The Impurity‐I (0.17 RRT) was isolated using prepar

Isolation, identification, and synthesis
Isolation, identification, and synthesis of two oxidative degradation products of olanzapine (LY170053) in solid oral formulations
✍ Steven W. Baertschi; Heiko Brunner; Charles A. Bunnell; Gary G. Cooke; Benjamin 📂 Article 📅 2008 🏛 John Wiley and Sons 🌐 English ⚖ 291 KB

Two impurities found in both stressed and aged solid-state formulations of olanzapine have been identified as (Z)-1,3-dihydro-4-(4-methyl-1-piperazinyl)-2-(2-oxopropylidene)-2H-1,5-benzodiazepin-2-one (1) and (Z)-1-[1,2-dihydro-4-(4-methyl-1-piperazinyl)-2-thioxo-3H-1,5-benzodiazepin-3-ylidene]propa

Conformational analysis and J(HCOH) of α
Conformational analysis and J(HCOH) of α-hydroxy-N-caproylhydrazobenzene, a degradation product of phenylbutazone
✍ G. A. Neville; D. V. C. Awang 📂 Article 📅 1970 🏛 John Wiley and Sons 🌐 English ⚖ 497 KB

## Abstract —Intramolecular OH… N hydrogen bonding between the hydroxylic and terminal amino groups of α‐hydroxy‐__N__‐caproylhydrazobenzene (**5**) permits __J__(HCOH) to be observed in most solvents. The configuration and conformation of **5** are discussed and an HCOH dihedral angle (ϕ) of 1