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Identification of cyclic nucleotide derivatives synthesized for radioimmunoassay development by fast atom bombardment with collision-induced dissociation and mass-analysed ion kinetic energy spectroscopy

✍ Scribed by Russell P. Newton; Andrea M. Evans; Hamed G. Hassan; Terence J. Walton; A. Gareth Brenton; Frank M. Harris

Publisher
John Wiley and Sons
Year
1993
Tongue
English
Weight
655 KB
Volume
28
Category
Article
ISSN
1076-5174

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✦ Synopsis

The syntheses of 2'-O-snccinyl, 2'-O-succinyltyrosinyl methyl ester and 2'-O-succinyliodotyrosinyl methyl ester derivatives of a cyclic nucleotide, derivatives necessary for the successful development of a specific radioimmunoassay, are described. Fast atom bombardment with collision-induced dissociation and mass-analysed ion kinetic energy spectroscopy were used to verify the positions of substitution and the retention of the 3',5'-cyclic phosphate moiety. Comparison of spectra produced after different iodination times permitted the optimization of the reaction conditions.

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✍ Russell P. Newton; Terence J. Walton; Salem A. Basaif; Andrea M. Jenkins; A. Gar 📂 Article 📅 1989 🏛 John Wiley and Sons 🌐 English ⚖ 887 KB

The syntheses of the dibutyryl derivatives of the 3',5'cyclic monophosphates of adenosine, guanosine and cytidine are described. The fast atom bombardment mass spectra of these compounds are discussed, together with the mass-analysed ion kinetic energy spectra of their protonated molecular ions and