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Identification of CpG oligodeoxynucleotide sequences that induce IFN-γ production in canine peripheral blood mononuclear cells

✍ Scribed by Keigo Kurata; Akira Iwata; Kenichi Masuda; Masahiro Sakaguchi; Koichi Ohno; Hajime Tsujimoto


Book ID
116965345
Publisher
Elsevier Science
Year
2004
Tongue
English
Weight
203 KB
Volume
102
Category
Article
ISSN
0165-2427

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## Abstract The immune system of vertebrates detects bacterial DNA as a “danger signal” based on the presence of unmethylated CpG motifs. We examined whether oligodeoxynucleotides (ODNs) with CpG motifs (CpG‐ODNs) also induce mobilization of hematopoietic progenitor cells (HPCs). Mice challenged wi