Identification of chick embryos homozygous for the Creeper factor

✍ Scribed by Cairns, John McKay ;Gayer, Kenneth

• Book ID: 102889064
• Publisher: John Wiley and Sons
• Year: 1943
• Tongue: English
• Weight: 908 KB
• Volume: 92
• Category: Article
• ISSN: 0022-104X
• DOI: 10.1002/jez.1400920207

✦ Synopsis

The Creeper factor in the fowl is a simple mendelian dominant which is lethal in the homozygous condition. Landauer and Dunn ( '30) showed that the chief lethal period occurs during the fourth day of incubation. A small percentage of homozygotes survive this early lethal period, but never hatch. These latter embryos develop malformations similar to mammalian phocomelia, and will be referred to as phocomelic embryos, while those which die during the early lethal period will be referred to as prothanic embryos (Cairns, '41).

IDENTIFICATION OF PROTHANIC CREEPER EMBRYOS

The first detailed description of the prothanic embryos was given by Landauer ( '32). He found that after 72 hours of incubation the prothanic embryos are easily recognized by a pronounced retardation of growth. Frequently a prothanic embryo incubated for 72 hours resembled a normal embryo incubated for 48 to 60 hours. The retardation in growth, however, was not uniform in all parts of the embryo. The Present circumstances will not permit a continuation of this work. Although a histological study is lacking, our data are communicated, since they may be of practical value to other workers.