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Identification of cell lineages involved by t(15;17) in acute promyelocytic leukemia by combined fluorescence activated cell sorting and FISH

✍ Scribed by Hong Chang; Xiao Ying Qi; D. Robert Sutherland


Book ID
113512562
Publisher
Elsevier Science
Year
2005
Tongue
English
Weight
295 KB
Volume
158
Category
Article
ISSN
0165-4608

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Identification of PML–RARA rearrangement
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Acute promyelocytic leukemia (APL) is characterized by a reciprocal translocation, t(15;17) (q22;q12), resulting in fusion of the genes promyelocytic leukemia (PML) and retinoic acid receptor alpha (RARA). With conventional cytogenetic methods, these translocations are detected in about 70-90% of pa