Identification of bla OXA-128 and bla OXA-129, two novel OXA-type extended-spectrum-β-lactamases in Pseudomonas aeruginosa, in Hunan Province, China
✍ Scribed by Wen'en Liu; Xiaoyi Liu; Jingzhong Liao; Yunli Zhang; Xianghui Liang
- Publisher
- John Wiley and Sons
- Year
- 2010
- Tongue
- English
- Weight
- 190 KB
- Volume
- 50
- Category
- Article
- ISSN
- 0233-111X
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✦ Synopsis
Abstract
We collected 97 non‐repetitive carbapenemases‐sensitive clinical isolates of Pseudomonas aeruginosa in Human Province, China, during the period of October 2006 to January 2007. From these isolates, we identified two novel oxacillin‐hydrolysing (OXA) type extended‐spectrum‐β‐lactamases (ESBLs): bla OXA‐128 and bla OXA‐129, which contain the mutations of I89V from bla OXA‐56 and K134N from bla OXA‐10, respectively. Clinical isolates containing either bla OXA‐128 or bla OXA‐129 show resistance to cephamycin‐class antibiotics but sensitive to carbapenem‐class antibiotics. The occurrence of novel OXA‐type lactamases suggests a regional prevalent pattern of ESBLs Pseudomonas aeruginosa in this area. (© 2010 WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim)