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Identification of antigenic epitopes recognized by Mac-2 binding protein-specific cytotoxic T lymphocytes for use in cancer immunotherapy

✍ Scribed by Yoshitomo Ozaki; Keiichi Kontani; Koji Teramoto; Takuya Fujita; Noriaki Tezuka; Satoru Sawai; Hiroyoshi Watanabe; Shozo Fujino; Tohru Asai; Iwao Ohkubo


Book ID
116288263
Publisher
Elsevier Science
Year
2004
Tongue
English
Weight
229 KB
Volume
317
Category
Article
ISSN
0006-291X

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We have derived HLA-A2.1-restricted, gastric cancerspecific cytotoxic T lymphocyte (CTL) lines by repetitive in vitro stimulation of tumor-associated lymphocytes (TAL) with autologous tumor cells. The HER2/neu specificity of these gastric cancer-specific CTLs was demonstrated using HER2/neu-transfec