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Identification of androgen-coregulated protein networks from the microsomes of human prostate cancer cells

✍ Scribed by Michael E Wright, Jimmy Eng, James Sherman, David M Hockenbery…

Book ID
120703432
Publisher
BioMed Central
Year
2003
Tongue
English
Weight
633 KB
Volume
5
Category
Article
ISSN
1465-6906

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## Background: The cyclin-dependent kinase inhibitor p27 is a putative tumor suppressor that is downregulated in the majority of human prostate cancers. the mechanism of p27 down-regulation in prostate cancers in unknown, but presumably involves increased proteolysis mediated by the scfskp2 ubiquit