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Identification of an Inhibitor of the MurC Enzyme, Which Catalyzes an Essential Step in the Peptidoglycan Precursor Synthesis Pathway

✍ Scribed by Zawadzke, Laura E.; Norcia, Michael; Desbonnet, Charlene R.; Wang, Hong; Freeman-Cook, Kevin; Dougherty, Thomas J.


Book ID
127048965
Publisher
Mary Ann Liebert
Year
2008
Tongue
English
Weight
928 KB
Volume
6
Category
Article
ISSN
1540-658X

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## Abstract In this paper, we describe the structure‐based design, synthesis, and biological evaluation of cytosine derivatives and analogues that inhibit IspF, an enzyme in the non‐mevalonate pathway of isoprenoid biosynthesis. This pathway is responsible for the biosynthesis of the C~5~ precursor