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Identification of a tumor-derived p53 mutant with novel transactivating selectivity

โœ Scribed by Pan, Yi; Haines, Dale S


Book ID
110063986
Publisher
Nature Publishing Group
Year
2000
Tongue
English
Weight
179 KB
Volume
19
Category
Article
ISSN
0950-9232

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Identification of a novel, transactivati
โœ Sona Pekova; Radek Cmejla; Lukas Smolej; Tomas Kozak; Martin Spacek; Miroslav Pr ๐Ÿ“‚ Article ๐Ÿ“… 2008 ๐Ÿ› Elsevier Science ๐ŸŒ English โš– 567 KB

p53 is implemented in many processes controlling cell fate. Recently it has been reported that besides post-translational modifications and regulation of protein-protein interactions, the activity of p53 is also substantially controlled at transcriptional level. In 109 out of 127 (86%) patients with