Identification of a specific effector of the small GTP-binding protein Rap2
β Scribed by Isabelle Janoueix-Lerosey; Evdokia Pasheva; Marie-France de Tand; Armand Tavitian; Jean de Gunzburg
- Book ID
- 114428995
- Publisher
- John Wiley and Sons
- Year
- 1998
- Tongue
- English
- Weight
- 458 KB
- Volume
- 252
- Category
- Article
- ISSN
- 1432-1327
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π SIMILAR VOLUMES
We report a novel crystal form of the small G protein Rap2A in complex with GTP which has no GTPase activity in the crystal. The asymmetric unit contains two complexes which show that a conserved switch I residue, Tyr 32, contributes an extra hydrogen bond to the β₯-phosphate of GTP as compared to re
## Abstract Rap1 is a small GTPβbinding protein (SMG) that exists in two 95% homologous isoforms, rap1A and rap1B. The functions of the rap1 proteins are not well understood. In this report we examined expression and function of rap1 in primary (HOKs) and immortalized (IHOKs) human oral keratinocyt