Mutations in the X-linked hypoxanthine-guanine phosphoribosyl transferase gene (HPRT) result in deficiencies of HPRT enzyme activity, which may cause either a severe form of gout or Lesch-Nyhan syndrome depending on the residual enzyme activity. Mutations leading to these diseases are heterogeneous
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Identification of a single nucleotide change in a mutant gene for hypoxanthine-guanine phosphoribosyltransferase (HPRTAnn Arbor)
โ Scribed by Shin Fujimori; Yuji Hidaka; Beverly L. Davidson; Thomas D. Palella; William N. Kelley
- Publisher
- Springer
- Year
- 1988
- Tongue
- English
- Weight
- 652 KB
- Volume
- 79
- Category
- Article
- ISSN
- 0340-6717
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The X-linked hypoxanthine-guanine phosphoribosyl-respectively. These data were similar to the reported transferase (hprt) gene is a target of analyses of in values. The mean MFs in the nine colon cancer pavivo mutation frequencies in circulating T-lympho-tients (10.6 { 7.3 1 10 06 ) were not signifi