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Identification of a second glycine-like fragment on the strychnine molecule

✍ Scribed by M. H. Aprison; Enrique Galvez-Ruano; K. B. Lipkowitz

Publisher: John Wiley and Sons
Year: 1995
Tongue: English
Weight: 406 KB
Volume: 40
Category: Article
ISSN: 0360-4012
DOI: 10.1002/jnr.490400314

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✦ Synopsis

Strychnine is a complex molecule that inhibits the physiological actions of glycine, an important inhibitory neurotransmitter in the spinal cord, brain stem, and other areas of many vertebrates. Since 1987, we have employed atomistic molecular modeling tools to find an explanation at the molecular level for how this antagonism works. We have located a second glycinelike fragment in the strychnine molecule that, when compared to glycine in a three pair atom analysis, provides an excellent topological and electronic charge congruence. The topological congruence in the second glycine-like fragment is much better than with the first fragment reported in 1987 when using a truncated strychnine molecule in the quantum mechanical analysis. A fourth negative atom, a characteristic of antagonists which we reported earlier (Aprison and Lipkowitz:

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