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Identification of a PP2A-interacting protein that functions as a negative regulator of phosphatase activity in the ATM/ATR signaling pathway

✍ Scribed by McConnell, J L; Gomez, R J; McCorvey, L R A; Law, B K; Wadzinski, B E

Book ID
110072404
Publisher
Nature Publishing Group
Year
2007
Tongue
English
Weight
306 KB
Volume
26
Category
Article
ISSN
0950-9232

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## Abstract Extracellular‐signal‐regulated kinase (ERK) undergoes rapid inactivation following the intense activation evoked by cerebral ischemia and reperfusion. However, the precise mechanism of this inactivation has not been elucidated. To investigate how phosphatases regulate the ERK cascade fo