Identification of a Potent Inhibitor of Human Dual-Specific Phosphatase, VHR, from Computer-Aided and NMR-Based Screening to Cellular Effects

Cover Picture: Identification of a Poten

Cover Picture: Identification of a Potent Inhibitor of Human Dual-Specific Phosphatase, VHR, from Computer-Aided and NMR-Based Screening to Cellular Effects (ChemBioChem 17/2007)

✍ Zhe Shi; Sartaj Tabassum; Wei Jiang; Jiahai Zhang; Suvigya Mathur; Jihui Wu; Yun 📂 Article 📅 2007 🏛 John Wiley and Sons 🌐 English ⚖ 53 KB

The cover picture shows a potent and competitive inhibitor, (glucosamine-aminoethoxy)triphenyltin (GATPT), of the dual-specific human vaccinia H1-related phosphatase (VHR). This inhibitor was successfully identified from a compound library, by combining a virtual-and NMR-based ligand-screening strat