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Identification of a P-Glycoprotein-Deficient Subpopulation in the CF-1 Mouse Strain Using a Restriction Fragment Length Polymorphism

✍ Scribed by Diane R. Umbenhauer; George R. Lankas; Todd R. Pippert; L.David Wise; Mark E. Cartwright; Steven J. Hall; Carolann M. Beare


Book ID
112266487
Publisher
Elsevier Science
Year
1997
Tongue
English
Weight
194 KB
Volume
146
Category
Article
ISSN
0041-008X

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The subpopulation of CF-1 mice deficient
✍ Todd R. Pippert; Diane R. Umbenhauer πŸ“‚ Article πŸ“… 2001 πŸ› John Wiley and Sons 🌐 English βš– 201 KB

## Abstract A subpopulation of the CF‐1 mouse strain is sensitive to neurotoxicity following exposure to avermectins, a family of structurally related antiparasitic agents. This unusual sensitivity is the result of a deficiency in the mdr1a P‐glycoprotein that normally contributes to a functional b