Identification of a novel variant of hepatitis E virus in Italy

✍ Scribed by Zanetti, Alessandro R.; Schlauder, George G.; Roman�, Luisa; Tanzi, Elisabetta; Fabris, Paolo; Dawson, George J.; Mushahwar, Isa K.

• Publisher: John Wiley and Sons
• Year: 1999
• Tongue: English
• Weight: 103 KB
• Volume: 57
• Category: Article
• ISSN: 0146-6615
• DOI: 10.1002/(sici)1096-9071(199904)57:4<356::aid-jmv5>3.0.co;2-d

✦ Synopsis

Hepatitis E infection is typically associated with areas in which hepatitis E virus (HEV) is endemic. Except for a few cases in Europe and in the United States, acute hepatitis E is usually associated with travel to endemic areas. We set out to determine the etiologic role of HEV in acute non-A-C hepatitis in Italy. The presence of HEV-RNA and antibody was determined in 218 patients diagnosed with acute viral non-A-C hepatitis. Acute hepatitis E infection was defined by the presence of HEV-RNA in sera and positivity for IgM anti-HEV and seroconversion to IgG anti-HEV. Acute hepatitis E was found in 10.1% of the patients with acute non-A-C, with 95.5% exhibiting a benign course. A more severe course was observed in a patient co-infected with HAV and HEV. Most cases were travelers to endemic areas, although 18.2% reported no travel. One patient was from a household with an infected patient. Sequence analyses of the polymerase chain reaction (PCR) product derived from a patient who never visited endemic areas, identified an isolate that is divergent significantly from all reported isolates of HEV (79.5-85.8% nucleotide identity). Evidence from this study suggests that HEV accounts for approximately 10% of acute non-A-C viral hepatitis in Italy, diagnosed generally in travelers returning from endemic areas. However, the identification of a new HEV variant in an individual who never indicated travel or contact with individuals associated with endemic areas, suggests that this virus may be native to Italy.