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Identification of a novel shunt product produced by a disruptant of the actVI-ORFA gene involved in the biosynthesis of actinorhodin in Streptomyces coelicolor A3(2)

✍ Scribed by Takaaki Taguchi; Yutaka Ebizuka; David A Hopwood; Koji Ichinose

Publisher: Elsevier Science
Year: 2000
Tongue: French
Weight: 157 KB
Volume: 41
Category: Article
ISSN: 0040-4039
DOI: 10.1016/s0040-4039(00)00824-8

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✦ Synopsis

NMR and MS spectroscopy elucidated the structure of a novel shunt product isolated from a disruptant of the actVI-ORFA gene involved in the biosynthesis of actinorhodin (ACT) in Streptomyces coelicolor A3(2). The product, 1,4-naphthoquinone-8-hydroxy-3-[(3S)-acetoxybutyric acid], was found without complete abolition of ACT production, implying that the ORFA product might stabilise the multicomponent, type II PKS complex and perhaps assist the chemically spontaneous dehydration of a hemiketal intermediate for ecient pyran ring formation.

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